Designing and evaluating medical deep learning systems

Can better design of deep learning studies lead to the faster transformation of medical practices? According to the authors of “Designing deep learning studies in cancer diagnostics,” published in Nature Reviews Cancer’s latest issue, the answer is yes. “We propose several protocol items that should be defined before evaluating the external cohort” says first author […]

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Gene network for leukemia factor

Transcription factors—proteins that regulate gene expression—play critical roles in cell fate decisions and are frequent targets of mutation in a variety of human cancers. Understanding how transcription factors contribute to disease requires the identification of their direct gene targets, but traditional methods are time-consuming and make it difficult to distinguish direct from secondary changes. Kristy […]

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Compound isolated from human sperm could treat genetic disorder

A newly discovered genetic condition caused by faulty protein synthesis which causes delayed development and learning difficulties could be treated by a compound originally isolated from human sperm, say scientists. The University of Manchester researchers, with collaborators from the UK, France and US, identified rare changes in a gene called EIF5A in seven children with […]

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In-silico modelling helps with the integrated study of the intervertebral disc in health and disease

The spinal column consists of 24 vertebrae that provide axial support to the torso and protection to the spinal cord that runs through its central cavity. The vertebrae are connected by means of intervertebral discs. These discs are highly hydrated, flexible and highly mechanically resistant. They allow the column its flexibility and act as shock […]

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